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KMID : 0525720130180010042
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Journal of Chitin and Chitosan
2013 Volume.18 No. 1 p.42 ~ p.47
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Effects of Starfish Polysaccharides on uPA, uPAR and VEGF Expressions
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Lee Kyu-Shik
Shin Jin-Sun
Nam Kyung-Soo
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Abstract
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The effects of starfish (Asterina pectinifera) polysaccharides on urokinase plasmonogen activator (uPA)/uPA receptor (uPAR) system-mediated metastasis and VEGF (vascular endothelial growth factor) proangiogenic factor expression in HT-29 human colorectal adenocarcinomas and MCF-7 human breast cancer cells were investigated. Transcriptions of uPA induced by TPA in both MCF-7 human breast cancer cells and HT-29 human colorectal adenocarcinomas were down-regulated by starfish polysaccharides in concentration ranges over 40 μg/mL and over 80 μg/mL, respectively. Also, uPAR expressions in both were decreased by the polysaccharides in a dose-dependent manner. The changes of VEGF in both cancer cells were significantly lessened in concentration ranges from 10 μg/mL to 120 μg/mL. The results suggest that starfish polysaccharides may prevent metastasis and angiogenesis in breast and colon cancers through the inhibition of uPA/uPAR system and VEGF expression. Therefore, present investigation demonstrates that starfish polysaccharides may use as a cancer chemoprventive agent for breast and colon cancers.
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KEYWORD
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Starfish polysaccharides, Cancer chemoprevention, Metastasis, urokinase Plasminogen activator, Vascular endothelial growth factor
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